Algorithms in Structural Bioinformatics - Aλγόριθμοι στη Δομική Βιοπληροφορική (Μ103) (ΤΠΙΒ ΥπΒ 8)

Ioannis Emiris - Evangelia Chrysina

Description

Integrative Structural Biology is an interdisciplinary field of research that addresses the emerging challenges of modern Biology at cellular and molecular level. The 3D structure of biological macromolecules such as proteins and nucleic acids improves our understanding of their function and their interactions with their counterparts at a molecular level. This allows the design of new drugs or therapeutic agents based on the 3D structure of the macromolecular targets of biomedical interest as well as improving the efficiency of targets involved in biotechnological processes. With the aim to delineate their structural features and convert the available information to knowledge algorithmic and structure-based approaches will be employed.

Selected topics covered by this course include:

  • Dynamic programming, and application to secondary structure prediction.
  • The Geometry of 3D Protein structure (bond lengths, angles, primary/secondary/tertiary/quaternary structure). Rotatable bonds, Rotame
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